- Title
- Tropheryma whipplei endocarditis: case presentation and review of the literature
- Creator
- McGee, Michael; Brienesse, Stephen; Chong, Brian; Levendel, Alexander; Lai, Katy
- Relation
- Open Forum Infectious Diseases Vol. 6, Issue 1, no. ofy330
- Publisher Link
- http://dx.doi.org/10.1093/ofid/ofy330
- Publisher
- Oxford University Press
- Resource Type
- journal article
- Date
- 2019
- Description
- Whipple's disease is a rare infective condition, classically presenting with gastrointestinal manifestations. It is increasingly recognized as an important cause of culture-negative endocarditis. We present a case of Whipple's endocarditis presenting with heart failure. A literature review identified 44 publications documenting 169 patients with Whipple's endocarditis. The average age was 57.1 years. There is a clear sex predominance, with 85% of cases being male. Presenting symptoms were primarily articular involvement (52%) and heart failure (41%). In the majority of cases, the diagnosis was made on examination of valvular tissue. Preexisting valvular abnormalities were reported in 21%. The aortic valve was most commonly involved, and multiple valves were involved in 64% and 23% of cases, respectively. Antibiotic therapy was widely varied and included a ceftriaxone, trimethoprim, and sulfamethoxazole combination. The average follow-up was 20 months, and mortality was approximately 24%. Physician awareness is paramount in the diagnosis and management of this rare condition.
- Subject
- endocarditis; Tropheryma whippeli; Whipple's disease
- Identifier
- http://hdl.handle.net/1959.13/1456098
- Identifier
- uon:45177
- Identifier
- ISSN:2328-8957
- Rights
- © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
- Reviewed
- Hits: 1518
- Visitors: 1648
- Downloads: 135
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 227 KB | Adobe Acrobat PDF | View Details Download |